Liquid pharmaceutical composition for the delivery of active ingredients
AssigneeNovaliq GmbH
InventorsBastian THEISINGER, Sonja THEISINGER, Bernhard GÜNTHER
Life of this patent
Estimating the term…
Abstract
The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble and/or hydrolytically sensitive drug substances. The compositions are designed as suspensions and have superior physical properties which make them highly useful as pharmaceutical delivery systems. The compositions may be administered topically into the eye, or injected via the subcutaneous or intramuscular route. The invention further provides kits comprising such compositions.
Claims21
1-14. (canceled)
A pharmaceutical composition in the form of a suspension comprising a dispersed phase in a liquid continuous phase wherein:
- (a) the dispersed phase comprises solid particles of an active ingredient, said ingredient being present in a therapeutically effective amount, and
- (b) the liquid continuous phase comprises a liquid vehicle comprising a semifluorinated alkane selected from F4H5, F4H6, F6H6 and F6H8;
- wherein the composition is substantially free of water, and wherein at least 90% of the particles of the active ingredient have a particle size of not more than about 200 μm.
Dependencies are inferred from the claim text.