Alum-containing coating formulations for microneedle vaccine patches
Assignee3M Innovative Properties Company
InventorPETER R. JOHNSON
Life of this patent
Estimating the term…
Abstract
Compositions for coating microneedles with aluminum-adjuvanted vaccines are provided comprising an aluminum-containing wet gel suspension selected from aluminum hydroxide wet gel suspension and aluminum phosphate wet gel suspension; a vaccine in an amount effective to stimulate an immune response in a mammal; a sugar, sugar alcohol, or combinations thereof; and a thickener. Some embodiments of the compositions have a viscosity of 500 to 30,000 cps when measured at 100 s−1 and temperature of 25 C. Microneedle devices coated with the compositions, as well as methods of forming the compositions and coating the microneedles, and methods of maximizing the aluminum content of vaccine-coated microneedle arrays are also provided.
Claims27
A composition comprising:
- an aluminum-containing wet gel suspension selected from aluminum hydroxide wet gel suspension and aluminum phosphate wet gel suspension;
- a vaccine in an amount effective to stimulate an immune response in a mammal;
- a sugar, sugar alcohol, or combinations thereof;
- and
- a thickener;
- wherein the composition has a viscosity of 500 to 30,000 cps when measured at 100 s−1 and temperature of 25° C.
(canceled)
(canceled)
(canceled)
(canceled)
23-24. (canceled)
A method of forming an aluminum-adjuvanted vaccine formulation comprising:
- providing a first aluminum-containing wet gel suspension selected from aluminum hydroxide wet gel suspension and aluminum phosphate wet gel suspension;
- concentrating the aluminum-containing wet gel suspension to produce a second aluminum-containing wet gel suspension;
- mixing at least one vaccine into the second aluminum-containing wet gel suspension in an amount effective to stimulate an immune response in a mammal to form the aluminum-adjuvanted vaccine formulation.
26-28. (canceled)
30-39. (canceled)
Dependencies are inferred from the claim text.