Nanocapsules carrying chikungunya-associated peptides
AssigneesAgency for Science, Technology and Research, Nanyang Technological University
InventorsFong Poh Lisa NG, Yi-Wing Jason KAM, Wei Ling Wen LEE, Fok Moon LUM, Sierin LIM, Kang YU, Chengxun SU
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Abstract
The present invention refers to a composition comprising a viral protein or fragment thereof, wherein the viral protein or fragment thereof is enclosed within a self-assembling protein nanocapsule, preferably ferritin, and wherein the viral protein, or fragment thereof is selected from a virus of the Togaviridae family. The viral protein or fragment thereof may also further be selected from a virus of the alphavirus subfamily.
Claims29
A composition comprising a viral protein or fragment thereof, wherein the viral protein, or fragment thereof is enclosed within a nanocapsule, and wherein the viral protein, or fragment thereof is selected from a virus of the Togaviridae family.
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A nucleic add sequence comprising a gene encoding a viral protein or fragment thereof a linker sequence and a scaffold protein;
- wherein
- the viral protein, or fragment thereof is enclosed within a nanocapsule, and wherein the viral protein, or fragment thereof is selected from a virus of the Togaviridae family;
- the scaffold protein is selected from the group consisting of ferritin, apoferritin and bacterioferritin,
A vector comprising a nucleic add sequence comprising a gene encoding a viral protein or fragment thereof a linker sequence and a scaffold protein;
- wherein
- the viral protein, or fragment thereof is enclosed within a nanocapsule, and wherein the viral protein, or fragment thereof is selected from a virus of the Togaviridae family;
- the scaffold protein is selected from the group consisting of ferritin, apoferritin and bacterioferritin.
An isolated host cell comprising a vector nucleic acid sequence comprising a gene encoding a viral protein or fragment thereof a linker sequence and a scaffold protein;
- wherein
- the viral protein, or fragment thereof is enclosed within a nanocapsule, and wherein the viral protein, or fragment thereof is selected from a virus of the Togaviridae family;
- the scaffold protein is selected from the group consisting of ferritin, apoferritin and bacterioferritin.
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Dependencies are inferred from the claim text.