Compositions, methods and uses for alpha-1 antitrypsin or derivatives thereof
OwnerJames D. Crapo, A. Mario Q. MARCONDES +1inventors
InventorsJames D. Crapo, A. Mario Q. MARCONDES, H. Joachim Deeg
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Abstract
Embodiments herein report methods and compositions for treating or preventing adverse effects of radiation therapies. In certain embodiments, compositions and methods relate to reducing or inhibiting damage due to acute, periodic or chronic radiation exposure.
Claims20
A method for ameliorating adverse effects of radiation exposure in a subject comprising, administering to a subject undergoing or scheduled to undergo radiation therapy a therapeutically effective amount of a composition comprising alpha-1 antitrypsin (AAT), a fragment thereof or a mutant thereof wherein the composition modulates the adverse effects of the radiation therapy in the subject.
A method for ameliorating adverse effects of exposure to whole body radiation comprising, administering to a subject having been exposed to whole body radiation a therapeutically effective amount of a composition comprising alpha-1 antitrypsin (AAT), a fragment thereof, a recombinant molecule thereof or a mutant thereof wherein the composition modulates the adverse effects of the radiation in the subject.
Dependencies are inferred from the claim text.