Treatment of right ventricular dysfunction due to pressure overload
AssigneeOttawa Hospital Research Institute
InventorsColin SUEN, Lynn MEGENEY, Duncan J. STEWART, Mohammad ABDUL-GHANI
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Abstract
A method is disclosed for inducing right ventricular (RV) adaptive remodeling in a patient suffering from pulmonary hypertension (PH) due to pressure overload comprising administering a therapeutically effective amount of a carditrophin-1 polypeptide, recombinant protein or a polynucleotide encoding CT-1 polypeptide or full-length protein.
Claims14
A method for treating a patient with right ventricular dysfunction due to pressure overload, by inducing right ventricular (RV) adaptive compensation in a patient, comprising administration of a therapeutically effective amount of a cardiotrophin-1 (CT-1) polypeptide to the patient to treat right heart failure (RVF).
(canceled)
A method for reversing RV maladaptive compensation in a patient with right ventricular dysfunction due to pressure overload comprising administration of a therapeutically effective amount of a cardiotrophin-1 (CT-1) polypeptide to the patient to treat right heart failure (RVF).
(canceled)
Dependencies are inferred from the claim text.