Anti-activin a antibodies and methods of use thereof for treating pulmonary arterial hypertension

A method of treating a subject having pulmonary arterial hypertension (PAH), comprising

• administering to the subject a therapeutically effective amount of an anti-Activin A antibody, or antigen-binding fragment thereof,
• wherein the therapeutic effect of administration of the anti-Activin A antibody, or antigen-binding fragment thereof, to the subject is selected from the group consisting of
• inhibits thickening of the pulmonary artery in the subject;
• increases stroke volume in the subject;
• increases right ventricle cardiac output in the subject;
• and
• extends survival time of the subject,
• thereby treating the subject having PAH.