SCAFFOLDS FOR THE TReATMENT OF SPINAL CORD INJURIES AND DISEASES
AssigneeTechnion Research & Deveiopment Foundation Limited
InventorsShulamit Levenberg, Sivan Ida Cohan-Matstiah
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Abstract
Methods of treating spinal cord injuries are disclosed. The method comprises implanting scaffolds comprising a protruding scaffold and a supporting scaffold, wherein at least a portion of the protruding scaffold is inserted into a lesioned area of the spinal cord so as to contact the injury or diseased site, wherein the supporting scaffold does not protrude into the injury or diseased site and is in contact with the rostral and/or caudal dura of the spinal cord.
Claims31
A method of treating a spinal cord injury or disease in a subject comprising implanting into the subject a scaffold, said scaffold comprising a protruding scaffold and a supporting scaffold, wherein at least a portion of said protruding scaffold is inserted into a lesioned area of the spinal cord so as to contact the injury or diseased site, wherein said supporting scaffold does not protrude into the injury or diseased site and is in contact with the rostral and/or caudal dura of the spinal cord, wherein said supporting scaffold and said protruding scaffold are in physical contact with one another following said implanting and said supporting scaffold is orientated with respect to said protruding scaffold to forma shape comprising a T following said implanting, thereby treating the spinal cord injury or disease.
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An article of manufacture comprising a first scaffold and a second scaffold wherein:
- (i) said first scaffold is seeded with cells and is of dimensions such that it is capable of protruding into a lesioned area of the spinal cord of a subject;
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- (ii) said second scaffold is not seeded with cells.
An article of manufacture comprising a T shaped or H shaped-scaffold, wherein the vertical portion of the T, or the horizontal portion of the H is of dimensions that it is capable of protruding into a lesioned area of the spinal cord of a subject.
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Dependencies are inferred from the claim text.