Back to results
US 2018/0008641 A1Published application
Use of MicroRNA 375 in Augmenting Stem Cell Based and Endogenous Ischemic Tissue Repair
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsRaj Kishore, Venkata Naga Srikanth Garikipati
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions and methods useful for treating ischemic injury. In one embodiment, the present invention uses an inhibitor of miR-375 in a cell to enhance its survival.
Claims20
A composition for treating ischemic injury comprising an inhibitor of microRNA (miR)-375.
A method of treating an ischemic heart in a subject, the method comprising:
- isolating a stem cell from a subject;
- inhibiting miR-375 in the isolated stem cell to generate an miR-375 inhibited stem cell;
- and
- administering the miR-375 inhibited stem cell to the subject.
1 more element
A method of enhancing cell survival, the method comprising administering to the cell an effective amount of an inhibitor of miR-375.
Dependencies are inferred from the claim text.