Pharmaceutical Compositions Comprising Ledipasvir And Sofosbuvir

A process for the preparation of a pharmaceutical composition comprising a compound of formula (I)

• or a pharmaceutically acceptable salt or solvate thereof and a compound of formula (II)
• or a pharmaceutically acceptable salt or solvate thereof, wherein the compound of formula (I) and the compound of formula (II) are in amorphous form, the process comprising the steps of:
• (i) providing a compound of formula (I) or a pharmaceutically acceptable solvate or salt thereof,
• (ii) providing a compound of formula (II) or a pharmaceutically acceptable salt thereof,
• (iii) mixing the compound of formula (I) or a pharmaceutically acceptable solvate or salt thereof and the compound of formula (II) or a pharmaceutically acceptable salt thereof,
• (iv) optionally blending the mixture provided in (iii) with at least one pharmaceutically acceptable excipient, and
• (v) optionally preparing a tablet based on the blend obtained in (iv).