Methods of treating neurological inflammatory disorders
AssigneeMayo Foundation for Medical Education and Research
InventorCharles L. Howe
Life of this patent
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Abstract
Methods of treating neurological inflammatory disease or seizures caused by neuroinflammation by administering cPMP are described. Treating neuroinflammatory and neurometabolic diseases with cPMP is described so as to override dyshomeostasis in the MoCo synthesis pathway and control synaptic inhibition in the gephyrin-GABAR pathway. This is a novel strategy for preventing neural circuit dyshomeostasis by stabilizing inhibitory synapses.
Claims14
A method of treating a neurological inflammatory disease in an individual, comprising:
- administering an effective amount of cPMP to the individual,
- thereby treating the individual.
A method of treating ALS, epilepsy or another seizure disorder in an individual, comprising:
- administering an effective amount of cPMP to the individual,
- thereby treating the individual.
A method of treating neuroinflammation-induced seizures in an individual, comprising:
- administering an effective amount of cPMP to the individual,
- thereby treating the individual.
Dependencies are inferred from the claim text.