Compositions Useful for Treating Herpes Simplex Keratitis, and Methods Using Same
AssigneeDrexel University
InventorsJane E. CLIFFORD, Oleg ALEKSEEV, Stephen R. JENNINGS
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to compositions and methods for treating diseases and disorders caused by herpes simplex virus type 1, including herpes simplex keratitis, in a subject. In certain embodiments, the compositions of the present invention comprise an ATM inhibitor and an anti-herpetic agent. In other embodiments, the compositions comprise a Chk2 inhibitor and an anti-herpetic agent. In yet other embodiments, the compositions comprise a Chk2 inhibitor and an ATM inhibitor, and optionally an anti-herpetic agent.
Claims18
A method of treating or preventing herpes simplex keratitis in a subject in need thereof, wherein the keratitis is caused by a drug-resistant HSV-1 strain, the method comprising administering to the subject an effective amount of at least one inhibitor selected from the group consisting of an ATM inhibitor and a Chk2 inhibitor, wherein the subject is optionally further administered an effective amount of an anti-herpetic agent, whereby herpes simplex keratitis is treated or prevented in the subject.
A composition comprising an anti-herpetic agent and at least one inhibitor selected from the group consisting of an ATM inhibitor, a Chk2 inhibitor, and a salt, solvate or N-oxide thereof, wherein the composition treats or prevents herpes simplex keratitis in a subject in need thereof.
A kit comprising at least one inhibitor selected from the group consisting of an ATM inhibitor and a Chk2 inhibitor, the kit further comprising an applicator;
- and an instructional material for the use of the kit, wherein the instruction material comprises instructions for treating, ameliorating or preventing herpes simplex keratitis in a subject in need thereof.
Dependencies are inferred from the claim text.