Novel egfr modulators and uses thereof

A compound of Formula (VIII):

• wherein
• X1 is O, NH, S, CH2, or CF2;
• R1 and R2 are independently selected from hydrogen, halo, C1-6 alkyl, and C1-6 haloalkyl;
• R3 is selected from halo, hydroxyl, C1-6 alkyl, C1-6 alkoxy, cyano, and nitro;
• n is a number from zero to 4;
• R4 is selected from hydrogen, C1-6 alkyl, C3-7 cycloalkyl, and —NR22R23;
• wherein the alkyl or cycloalkyl is unsubstituted or substituted with hydroxyl or amino;
• and
• wherein each R22 and R23 are independently selected from hydrogen and C1-6 alkyl or R22 and R23 may be joined to form a 3 to 10 membered ring;
• R5 is selected from hydrogen and C1-6 alkyl;
• R6 is selected from hydrogen, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, cyano, and nitro;
• R7 is selected from hydrogen, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, cyano, and nitro;
• R8 is selected from hydrogen, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, cyano, and nitro;
• Q is CR9 or N;
• R9 is selected from hydrogen, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, cyano, and nitro;
• R11 is selected from hydrogen and C1-6 alkyl;
• R12 is selected from hydrogen and C1-6 alkyl;
• R13 is selected from hydrogen, C1-6 alkyl, C1-6 acyl, SO2—C1-6alkyl, C3-7 cycloalkyl, and C6-20 aryl,
• wherein each alkyl or aryl is unsubstituted or substituted with hydroxyl, C1-6 alkoxy, or halo;
• and
• —NR18R19 is
• wherein R10 is selected from hydrogen and C1-6 alkyl;
• R15 is unsubstituted methyl, or is C2-4alkyl unsubstituted or substituted with hydroxy, methoxy, or halo;
• and
• m is 1 or 2;
• or R19 and R9 taken together form a 5- or 6-membered heteroaryl ring optionally substituted with C1-6alkyl that is unsubstituted or substituted with amino, hydroxyl, or halo;
• and R18 is hydrogen or C1-6alkyl, or is absent to satisfy valency of the heteroaryl ring;
• provided that neither of R6 or R7 is methoxy when —NR18R19 is
• or a pharmaceutically acceptable salt thereof.