Extended release compositions of an aminoalkyl nitrate
AssigneeCardiolynx AG
InventorsDirk SARTOR, Pierre VANKAN, Hubert STUCKLER, Armin SCHERHAG
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Abstract
The present invention relates to extended release compositions of an amino-C2-C6-alkyl nitrate and of pharmaceutically acceptable salt thereof, in particular 2-aminoethyl nitrate, and to fixed dose combinations with further pharmaceutically active drug substances. 2-Aminoethyl nitrate does not provoke nitrate tolerance, but has a very short half life in physiological systems.
Claims16
An extended release composition of an amino-C2-C6-alkyl nitrate and of pharmaceutically acceptable salts thereof, wherein release is over 4-24 hours.
A method of treatment of arterial hypertension, Raynaud's disease, morbus Menière, or argininosuccinic aciduria (ASA), comprising administering a therapeutically effective amount of an extended release composition of 2-aminoethyl nitrate.
Dependencies are inferred from the claim text.