Methods of making and using compositions comprising flavonoids
AssigneeVizuri Health Sciences LLC
InventorPhilip J. BIRBARA
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Abstract
The subject invention relates to novel micoparticulate and soluble forms of flavonoids, and their synthesis. The invention also includes novel formulations of such flavonoids. Further, the invention includes novel methods of manufacturing the flavonoid formulations. The invention also relates to a wide variety of applications of the flavonoid formulations.
Claims19
A composition comprising:
- a flavonoid, preferably apigenin, and
- a heat stable flavonoid solubilizing compound, preferably a nonionic surfactant,
- wherein said composition is formed by mixing the flavonoid and said heat stable flavonoid solubilizing compound to a temperature where said flavonoid is dissolved in said surfactant, and wherein the composition is preferably in the form of a food supplement, dietary supplement or medical food.
A method of producing a hydrated flavonoid, comprising:
- mixing a flavone with an alkali metal hydroxide to form an aqueous solution of an alkali metal flavone salt;
- acidifying the aqueous solution of an alkaline metal flavonoid salt with an acidic agent to a pH level of less than 7 to form a hydrated flavonoid precipitate,
- wherein the acidifying step is done under conditions producing flavonoid nanofibers having an average size of 50-1000 nanometers.
A method of producing a hydrated flavonoid, preferably hydrated apigenin or hydrated luteolin, comprising:
- dissolving a flavonoid in a non-toxic organic solvent to form a mixture, wherein the dissolving step is preferably done at a temperature of about 20° C. to below the boiling point of the organic solvent;
- and
- adding water to the mixture to form a hydrated flavonoid precipitate;
- wherein the adding water step is done under conditions producing flavonoid nanofibers having an average size of 50-1000 nanometers.
A method of forming a topical formulation of a hydrated flavonoid comprising:
- mixing a flavonoid with an alkali metal hydroxide in water to form an alkali metal flavonoid salt solution;
- adding the alkali metal flavonoid salt solution to a dermatologically acceptable carrier,
- adjusting the pH of the formulation to a dermatologically acceptable pH, preferably 4 to 8,
- wherein the adjusting the pH step is done under conditions producing flavonoid nanofibers having an average size of 50-1000 nanometers.
A method of preparing a topical formulation of a hydrated flavonoid comprising:
- solubilizing a flavonoid in an alcohol;
- adding the alcohol solubilized flavonoid to a dermatologically acceptable carrier,
- adjusting the pH of the formulation to a dermatologically acceptable pH, preferably 4 to 8,
- wherein the adjusting the pH step is done under conditions producing flavonoid nanofibers having an average size of 50-1000 nanometers.
A method of preparing a topical formulation of a flavonoid comprising:
- adding a flavonoid to an emulsion carrier, preferably an oil in water, or water in oil emulsion carrier, to form a mixture;
- heating the mixture until it has the approximate viscosity of water, wherein the mixture is preferably heated to about 120° F.-170° F., and
- forming a dispersion of microparticles in the mixture using cavitational forces.
A method of preparing a solubilized flavonoid composition comprising:
- mixing flavonoid particles with a heat stable flavonoid solubilizing compound, preferably a nonionic surfactant, more preferably a polysorbate when said flavonoid is apigenin, to form a mixture,
- heating the mixture to a temperature where the flavonoid particles are solubilized to form a solution, and
- cooling the solution.
Dependencies are inferred from the claim text.