Modified cyclodextrin coated magnetite nanoparticles for targeted delivery of hydrophobic drugs

A process for the preparation of Beta-cyclodextrin-citrate coated magnetic nanoparticles comprising the steps of:

• i. dissolving β-cyclodextrin and citric acid in a ratio ranging between 3:1 to 5:2 in water followed by stirring the mixture at a temperature in a range of 70-80° C. for period in the range of 3-4 hrs to obtain a transparent solution;
• ii. treating the transparent solution as obtained in step (i) with alcohol, followed by washing and drying at a temperature in the range of 60-70° C. for a period in the range of 24-26 hrs to obtain cyclodextrin-citrate complex;
• iii. dissolving cyclodextrin-citrate complex as obtained in step (ii) in water to obtain a cyclodextrin-citrate solution;
• iv. mixing ferric chloride hexahydrate and ferrous chloride tetrahydrate molar ratio ranging from 2:1 to 5:3 in water and ammonium hydroxide solution followed by stirring and washing to obtain magnetic nanoparticle;
• v. redispersing the magnetic nanoparticles as obtained in step (iv) followed by adding the Cyclodextrin-citrate solution as obtained in step (iii) with stirring for period in the range of 4-5 hours at temperature in the range of 80-90° C. to obtain a stable dispersion of beta-cyclodextrin coated magnetite nanoparticles;
• vi. dialyzing the beta-cyclodextrin coated magnetite nanoparticles dispersion obtained in step (v) against water for a period in range of 3-4 days and at a temperature in the range of 60-70° C. to obtain coated solid nanoparticles;
• vii. dispersing the coated nanoparticles obtained in step (vi) in water at the physiological pH to obtain Beta-cyclodextrin-citrate coated magnetite nanoparticles;