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AssigneeFerring B.V.
InventorsJanet Anne Halliday, Denis Andrew Carr, Alistair Chassels Ross, Claire Donaldson Young, Paul McDonald, Mohammad Siddique Qadir, Robert Victor Cochrane, Gouher Rabani, Joan Carles Arce Saez, Axel Niclas Petri
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The present invention is based on the identification of a cohort of polyurethane block copolymers that are particularly suited for use in pharmaceutical polymeric drug-device units and which offer improved control of drug release. In particular, there is provided a polymeric drug-device unit comprising a polyurethane block copolymer obtainable by reacting together a poly(alkylene oxide); a difunctional compound; a difunctional isocyanate; and optionally a block copolymer comprising poly(alkylene oxide) blocks; and quinagolide as a pharmaceutically active agent. The drug-device units may find application in the treatment and/or prevention of endometriosis.
A polymeric drug-device unit comprising:
A method of making a polymeric drug-device unit for the intravaginal administration of quinagolide or a pharmaceutically acceptable salt thereof, said method comprising reacting together:
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A method of treating or preventing endometriosis, said method comprising the step of administering to a subject in need thereof a therapeutically effective amount of the quinagolide metabolites N-desethyl and/or N,N-didesethyl.
Dependencies are inferred from the claim text.