Topical glycopyrrolate formulations

A glycopyrrolate solution comprising:

• about 0.5 to about 4.0% w/w of a glycopyrrolate compound having the following formula:
• wherein X− is a pharmaceutically acceptable counter ion salt;
• ethanol and water in a weight ratio of about 50:50 to about 60:40;
• a buffering agent, comprising an acid and a base, said acid and base at a total concentration of about 0.2 to about 0.5% w/w and at an acid:base ratio sufficient to maintain a pH of the glycopyrrolate solution of about 3.5 to about 6 at 25° C.;
• wherein the acid is citric acid and the base is selected from the group consisting of sodium citrate and tromethamine;
• wherein the pharmaceutically acceptable counter salt is prepared from an inorganic or organic acid selected from hydrochloric acid, hydrobromic acid, hydrogen fluoride, hydrogen iodide, sulfuric acid, nitric acid, phosphoric acid, acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, malic acid, malonic acid, succinic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluene-sulfonic acid, and salicylic acid.