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US 2018/0008239 A1Published application
Diagnostic devices and methods for mitigating hook effect and use thereof
AssigneeEllume Limited
InventorsRhiannon MCBEAN, Scott FRY, Sean PARSONS
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Abstract
The present disclosure relates to devices and methods for identifying conditions in a human or animal body, such as pregnancy or ovulation. For example, the present disclosure relates to devices and methods for identifying pregnancy or ovulation, which devices and methods are adapted to mitigate the “hook effect”, thereby improving accuracy of the devices and methods.
Claims18
An apparatus for detecting pregnancy and/or ovulation in a subject, said apparatus comprising one or more lateral flow test strips comprising:
- (a) a label-holding portion comprising:
- (i) a first mobilisable capture reagent comprising a detectable label, wherein the first capture reagent is configured to bind to human chorionic gonadotropin (hCG) to form a first complex;
- and
- (ii) a second mobilisable capture reagent comprising a detectable label, wherein the second capture reagent is configured to bind to Luteinizing Hormone (LH) to form a second complex;
- (b) a first test portion comprising an immobilised capture reagent configured to specifically bind hCG and thereby immobilise hCG to the first test portion;
- and
- (c) a second test portion comprising an immobilised capture reagent configured to bind to both hCG and LH and thereby immobilise hCG and/or LH to the second test portion.
4 more elements
Dependencies are inferred from the claim text.