Electron Induced Dissociation Devices and Methods
AssigneeDH Technologies Development Pte. Ltd.
InventorTakashi BABA
Life of this patent
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Abstract
A method and apparatus for conducting reactions between precursor ions and reagent ions, for example, a reaction between a precursor cation and an electron, such as ECD, are disclosed. The apparatus comprises first, second, and third pathways, each of which extends at least partially along a central axis, and wherein the second central axis is orthogonal to the first and third central axes. Charged species can be introduced into the second pathway as the ions are transmitted therethrough, thereby increasing precursor ion and charged species interaction without simultaneous trapping of the species.
Claims20
An ion reaction apparatus, comprising:
- a first plurality of electrodes arranged to define a first pathway therebetween, the first pathway comprising a first axial end configured to receive ions from an ion source and a second axial end disposed at a distance from the first axial end of the first pathway extending at least partially along a first central axis;
- a second plurality of electrodes arranged to define a second pathway extending along a second central axis, said second pathway intersecting the first pathway at a first intersection point, the second central axis being substantially orthogonal to the first central axis;
- a third plurality of electrodes arranged to define a third pathway therebetween, the third pathway comprising a first axial end and a second axial end disposed at a distance from the first axial end of the third pathway to transmit at least one of ions and reaction products of said ions out of the ion reaction apparatus, said third pathway extending at least partially along a third central axis substantially orthogonal to the second central axis and intersecting the second pathway at a second intersection point spaced a distance apart from the first intersection point, wherein the first, second, and third plurality of electrodes are configured to couple to an RF voltage source that provides an RF voltage to each of electrodes of the first, second, and third plurality of electrodes;
- and
- a charged species source for introducing a charged species into the second pathway along the second central axis extending between the first and second intersection points.
A method for performing an ion reaction, comprising:
- introducing a plurality of ions into a first pathway extending at least partially along a first central axis and defined by a first plurality of electrodes, the first pathway comprising a first axial end configured to receive ions from an ion source and a second axial end disposed at a distance from the first axial end of the first pathway;
- transmitting the ions into a second pathway extending along a second central axis and defined by a second plurality of electrodes, said second pathway intersecting the first pathway at a first intersection point, the second central axis being substantially orthogonal to the first central axis;
- transmitting the ions into a third pathway extending along a third central axis and defined by a third plurality of electrodes, said third pathway intersecting the second pathway at a second intersection point spaced a distance apart from the first intersection point, the third central axis being substantially orthogonal to the second central axis;
- and
- introducing a charged species into the second pathway along the second central axis extending between the first and second intersection points to allow the ions transmitted along the second pathway and the charged species to interact.
Dependencies are inferred from the claim text.