System and method for longitudinal data processing

A system for synchronization of a longitudinal data set from a subject, comprising:

• a database unit configured to store a first ensemble registration estimate corresponding to a first image ensemble, wherein the first ensemble registration estimate comprises a first reference image and a first set of transformations corresponding to a common co-ordinate space;
• a data acquisition unit communicatively coupled to an imaging device and the database unit and configured to:
• receive the first ensemble registration estimate from the database unit;
• and
• receive a second image ensemble image different from the first image ensemble, from the imaging device, wherein the first image ensemble and the second image ensemble are part of the longitudinal data set corresponding to a subject;
• a processor unit and a memory unit communicatively coupled to the database unit via a communications bus and configured to:
• determine a second reference image based on the first reference image and the second image ensemble;
• determine a second ensemble registration estimate corresponding to the second image ensemble based on the first image ensemble, the first ensemble registration estimate, and the second reference image using an optimization technique, wherein the second ensemble registration estimate comprises the first set of transformations, a second set of transformations corresponding to the second image ensemble, the second reference image, and a reference transformation for transforming the first reference image to the second reference image;
• generate a synchronized image ensemble based on the first ensemble image ensemble and the second ensemble image ensemble based on the second ensemble registration estimate;
• and
• determine a medical condition of the subject by a medical practitioner, based on the synchronized image ensemble.

A non-transitory computer readable medium encoded with a program having instructions to instruct at least one processor unit to synchronize a longitudinal data set from a subject, the synchronization technique comprising:

• receiving a first ensemble registration estimate corresponding to a first image ensemble, wherein the first ensemble registration estimate comprises a first reference image and a first set of transformations corresponding to a common co-ordinate space;
• receiving a second image ensemble different from the first image ensemble, wherein the first image ensemble and the second image ensemble are part of the longitudinal data set corresponding to the subject;
• determining a second reference image based on the second image ensemble and the first reference image;
• determining a second ensemble registration estimate based on the first ensemble registration estimate, the second reference image, the first image ensemble and the second image ensemble using an optimization technique, wherein the second ensemble registration estimate comprises the first set of transformations, a second set of transformations corresponding to the second image ensemble and a reference transformation for transforming the first reference image to the second reference image;
• generating a synchronized image ensemble corresponding to the first image ensemble and the second image ensemble based on the second ensemble registration estimate;
• and
• determining a medical condition of the subject by a medical practitioner based on the synchronized image ensemble.