Devices for detection of an analyte in urine and methods of using same
OwnerJohn P. Studdiford, Mairead H. Studdifordinventors
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Abstract
Disclosed herein are devices for detecting presence and/or amount of an analyte, such as glucose, in a urine sample when diluted in a toilet bowl containing water and methods of using same. The disclosed devices eliminate the need to handle urine samples or a device that has been contacted with a urine sample, and can be conveniently disposed of by flushing into a sewage or septic system.
Claims17
A method of detecting glucose in urine of a diabetic subject taking an amount of a sodium glucose cotransporter 2 (SGLT2) inhibitor, the method comprising:
- placing in a toilet bowl containing water a device that comprises an absorbent substrate having one or more reagents in an amount sufficient to react with glucose present in the toilet bowl containing water and urine and produce a visually detectable color change in a detection region of the device or a visually detectable color change in the water of the toilet bowl;
- collecting urine from the diabetic subject in the toilet bowl;
- waiting a predetermined period of time;
- and
- visually determining presence or absence of a color change in the detection region of the device or a visually detectable color change in the water of the toilet bowl to obtain a test result,
- recording the test result;
- communicating the test result to a health care provider;
- and
- monitoring the effectiveness of the SGLT2 inhibitor based on the test result,
- wherein glucose is determined to be present in the urine where the detection region changes color or the water of the toilet bowl changes color, wherein the presence of glucose above a threshold level indicates that the SGLT2 inhibitor is effective in the diabetic subject, wherein the device is paper, and wherein the device further comprises a positive control region spatially separated from the detection region and comprising glucose and one or more reagents for detection of glucose.
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A device for detecting glucose in a toilet bowl containing water and urine, the device comprising:
- an absorbent substrate comprising a first detection region having one or more reagents in an amount sufficient to react with glucose present in the toilet bowl containing water and urine and produce a visually detectable color change in the first detection region or a visually detectable color change in the water of the toilet bowl.
Dependencies are inferred from the claim text.