Diagnostic Assays and Kits for Detection of Folate Receptor 1
AssigneeImmunoGen, Inc.
InventorsChristina N. CARRIGAN, Olga AB, Daniel TAVARES, Beni B. WOLF
Life of this patent
Estimating the term…
Abstract
The invention generally relates to antibodies that bind to human folate receptor 1 and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.
Claims24
1-72. (canceled)
A nucleic acid molecule comprising a polynucleotide sequence encoding an antibody, antigen-binding fragment thereof, or polypeptide that specifically binds to the same FOLR1 epitope as, and competitively inhibits the binding to FOLR1 of, an antibody selected from the group consisting of:
- (a) an antibody comprising the variable heavy chain (VH) polypeptide of SEQ ID NO:25 and the variable light chain (VL) polypeptide of SEQ ID NO:29;
- (b) an antibody comprising the variable heavy chain (VH) polypeptide of SEQ ID NO:26 and the variable light chain (VL) polypeptide of SEQ ID NO:30;
- (c) an antibody comprising the variable heavy chain (VH) polypeptide of SEQ ID NO:27 and the variable light chain (VL) polypeptide of SEQ ID NO:31;
- and
- (d) an antibody comprising the variable heavy chain (VH) polypeptide of SEQ ID NO:28 and the variable light chain (VL) polypeptide of SEQ ID NO:32.
77-86. (canceled)
88-89. (canceled)
92-162. (canceled)
A nucleic acid molecule comprising a polynucleotide sequence encoding a polypeptide comprising selected from the group consisting of:
- (a) SEQ ID NO:25;
- (b) SEQ ID NO:26;
- (c) SEQ ID NO:27;
- and
- (d) SEQ ID NO:28.
A nucleic acid molecule comprising a polynucleotide sequence encoding a polypeptide comprising a sequence selected from the group consisting of:
- (a) SEQ ID NO:29;
- (b) SEQ ID NO:30;
- (c) SEQ ID NO:31;
- and
- (d) SEQ ID NO:32.
Dependencies are inferred from the claim text.