System, method, and module for biomarker detection

A method of detecting presence or absence of a biomarker in a sample, comprising:

• exposing a waveguide to the sample and binding the biomarker via a recognition element affixed to the waveguide;
• producing electromagnetic radiation directed at the waveguide, the waveguide guiding the electromagnetic radiation towards a detector;
• receiving the electromagnetic radiation at the detector;
• detecting a signal at the detector corresponding to the interaction of the electromagnetic radiation with the biomarker bound to the recognition element, in accordance with at least one detection modality;
• and
• determining presence or absence of the biomarker, by a computing device having one or more processors, by analyzing data related to the signal.

A biosensor module for use in a system for detecting a biomarker in a sample, the system comprising a light source for producing electromagnetic radiation and a detector for receiving the electromagnetic radiation and detecting a signal corresponding to an interaction of the electromagnetic radiation with the biomarker, the biosensor module comprising:

• a first plate;
• a second plate;
• a waveguide for guiding the electromagnetic radiation and positioned between the first and second plates, the waveguide having a first portion integral with the first plate and a second portion integral with the second plate;
• and
• a recognition element affixed to a portion of the waveguide, the recognition element configured to bind to the biomarker.