Method for detecting single molecule
AssigneesTsinghua University, Hon Hai Precision Industry Co., Ltd.
InventorsYUAN-HAO JIN, QUN-QING LI, SHOU-SHAN FAN
Life of this patent
Estimating the term…
Abstract
The disclosure relates to a method for detecting single molecule. The method includes: providing a carrier; detection disposing a single molecule sample on the carrier, and detecting the single molecule sample with a detector. The carrier includes a substrate and a metal layer on the substrate, wherein the substrate includes a base and a patterned bulge located on a surface of the base, the patterned bulge includes a number of strip-shaped bulges intersected with each other to form a net and define a number of holes, and the metal layer is located on the patterned bulge. The method is more accurate because the carrier has a relative higher SERS and can enhance the Raman scattering.
Claims20
A method for detecting single molecule, the method comprising:
- providing a carrier comprising a substrate and a metal layer located on the substrate, wherein the substrate comprises a base and a patterned bulge located on a surface of the base, the patterned bulge comprises a plurality of strip-shaped bulges intersected with each other to form a net and define a plurality of holes, and the metal layer is located on the patterned bulge;
- disposing a single molecule sample on a surface of the metal layer;
- and
- detecting the single molecule sample with a detector.
A method for detecting single molecule, the method comprising:
- providing a carrier comprising a substrate and a metal layer located on the substrate, wherein the substrate comprises a base and a patterned bulge located on a surface of the base, the patterned bulge comprises a plurality of strip-shaped bulges intersected with each other to form a net and define a plurality of holes, and the metal layer is located on the patterned bulge;
- placing the carrier in a chamber, wherein the chamber comprises an inputting hole and an outputting hole;
- making a single molecule liquid flow in to the chamber from the inputting hole and out of the chamber from the outputting hole so that some of the single molecule liquid is assembled on the metal layer to form a single molecule sample;
- and
- detecting the single molecule sample with a detector.
Dependencies are inferred from the claim text.