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US 2018/0003631 A1Published application
Surface plasmon resonance approach to monitor protein-ligand interactions
AssigneesThe Johns Hopkins University, Le Centre National De La Recherche Scientifique
InventorsFrank Bosmans, Pierre E. Bougis, Marie-France Eauclair
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Abstract
The present invention provides assays utilizing SPR to detect protein-ligand interactions as well as compositions utilized is such assays.
Claims34
A method of identifying a ligand that binds to a paddle motif peptide, the method comprising:
- a) contacting a paddle motif peptide immobilized on a sensor chip with a test molecule;
- b) detecting binding of the ligand and the paddle motif peptide using surface plasmon resonance (SPR), thereby identifying the test molecule as a ligand that binds the paddle motif peptide.
A sensor chip for use in a surface plasmon resonance (SPR) assay, the chip comprising a paddle motif peptide immobilized thereon.
The chip of claim 23, wherein the paddle motif peptide consists of SEQ ID NO:
- 2.
A paddle motif peptide comprising SEQ ID NO:
- 2.
A paddle motif peptide comprising SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.