Method of diagnosis and treating gastrointestinal and neurological diseases associated with species of genus clostridium
AssigneeThe United States of America as represented by the Department of Veterans Affairs
InventorsSydney M. Finegold, Paula Carlson
Life of this patent
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Abstract
The invention includes a method of diagnosis and treating autism associated with an overgrowth of beta2-toxin-gene-positive Clostridium perfringens in the gut of an autistic subject. In one embodiment, the method comprises administering to the subject (e.g. a subject having an overgrowth of beta2-toxin-gene-positive Clostridium perfringens in the gut) one or more agents to reduce or eliminate beta2-toxin-gene positive Clostridium perfringens in the subject so as to relieve one or more symptoms of autism.
Claims33
A method of treating autism associated with an overgrowth of beta2-toxin-gene-positive Clostridium perfringens in the gut of an autistic subject comprising administering to the subject having an overgrowth of Clostridium perfringens positive for beta2-toxin gene one or more agents to reduce or eliminate beta2-toxin-gene positive Clostridium perfringens in the subject so as to relieve one or more symptoms of autism;
- thereby, treating autism associated with an overgrowth of beta2-toxin-gene-positive Clostridium perfringens in the autistic subject.
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A method of treating autism associated with an overgrowth of beta2-toxin-gene-positive Clostridium perfringens in the gut of an autistic subject comprising:
- a) determining existence of an overgrowth of Clostridium perfringens positive for beta2-toxin gene in a sample from the subject;
- and (b) administering to the subject one or more agents to reduce or eliminate beta2-toxin-gene positive Clostridium perfringens in the subject so as to relieve one or more symptoms of autism;
- thereby, treating autism associated with an overgrowth of beta2-toxin-gene-positive Clostridium perfringens in the autistic subject.
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A method of identifying an autistic subject whose autism may be alleviated by a course of treatment directed against an overgrowth of Clostridium perfringens so as to reduce or eliminate the overgrowth comprising (a) determining existence of said overgrowth in the autistic subject, thereby, identifying the autistic subject whose autism may be alleviated by a course of treatment directed against the overgrowth of Clostridium perfringens.
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Dependencies are inferred from the claim text.