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US 2018/0002740 A1Published application
Transcription factor decoys, compositions and methods
AssigneeProcarta Biosystems Ltd.
InventorMichael McArthur
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Abstract
Compositions and methods for identifying and using cis-regulatory and decoy sequences are disclosed.
Claims22
A method of treating a bacterial infection, the method comprising administering a decoy polynucleotide comprising a binding site for a transcription factor,
- wherein the transcription factor binding site in the decoy polynucleotide is not operably linked to a gene;
- and
- wherein the decoy polynucleotide reduces binding of the transcription factor to a cis-regulatory sequence in a prokaryotic cell and causes an alteration in expression of gene or genes operably linked to the cis-regulatory sequence in the cell.
A method for modulating antibiotic resistance of a prokaryotic cell, the method comprising administering a decoy polynucleotide comprising a binding site for a transcription factor;
- wherein the transcription factor binding site in the decoy polynucleotide is not operably linked to a gene;
- and
- wherein the decoy polynucleotide reduces binding of the transcription factor to a cis-regulatory sequence in the prokaryotic cell and causes an alteration in expression of the operably linked gene or genes in the cell, thereby modulating antibiotic resistance of the cell.
Dependencies are inferred from the claim text.