Methods and compositions for targeted gene transfer
AssigneeThe University of North Carolina at Chapel Hill
InventorsAravind Asokan, Giridhar Murlidharan, Shen Shen
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Abstract
The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus capsids and virus vectors comprising the modified AAV capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.
Claims32
An adeno-associated virus (AAV) serotype 4 (AAV4) capsid protein, wherein the AAV4 capsid protein comprises a modification at amino acid residues K492, K503 and N585 and further comprises a modification at one or more of amino acid residues M523, G580, G581, Q583, S586, N587, L588, T590, D592, R593, L594, T595 and/or A596 in any combination, wherein the numbering of the residues is based on the amino acid sequence of SEQ ID NO:1.
An adeno-associated virus (AAV) serotype 4 (AAV4) capsid protein, wherein the AAV4 capsid protein comprises a modification at amino acid residues K493, K504 and N586 and further comprises a modification at one or more of amino acid residues M524, G581, G582, Q584, S587, N588, L589, T591, D593, R594, L595, T596 and/or A597 in any combination, wherein the numbering of the residues is based on the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.