Wise/sost nucleic acid sequences and amino acid sequences
OwnerRobb KRUMLAUF, Debra ELLIESinventors
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Abstract
The present invention relates to nucleic acid sequences and amino acid sequences which influence bone deposition, the Wnt pathway, ocular development, tooth development, and may bind to LRP. The nucleic acid sequence and polypeptides include Wise and Sost as well as a family of molecules which express a cysteine knot polypeptide. Additionally, the present invention relates to various molecular tools derived from the nucleic acids and polypeptides including vectors, transfected host cells, monochronal antibodies, Fab fragments, and methods for impacting the pathways.
Claims12
A method for modulating bone deposition comprising contacting a host cell with an antibody to Sost, wherein the antibody prevents wild-type Sost from binding with a Sost binding partner, wherein the Sost binding partner is an LRP having an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 68, 73, 76, 79, 84, and 86.
A composition for modulating bone deposition comprising an antibody to Sost, wherein the antibody prevents wild-type Sost from binding with a Sost binding partner, wherein the Sost binding partner is an LRP having an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 68, 73, 76, 79, 84, and 86.
Dependencies are inferred from the claim text.