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US 2018/0002693 A1Published application
Compositions and methods
AssigneeIonis Pharmaceuticals, Inc.
InventorsThazha P. Prakash, Punit P. Seth, Eric E. Swayze
Life of this patent
Estimating the term…
Abstract
Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.
Claims21
A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide is 10-30 linked nucleosides in length and has the nucleobase sequence of SEQ ID NO:
- 55, wherein the conjugate group comprises:
- and wherein the conjugate group is linked to the modified oligonucleotide at the 5′ end of the modified oligonucleotide.
2-40. (canceled)
47-54. (canceled)
60-213. (canceled)
(canceled)
Dependencies are inferred from the claim text.