Chemical approaches for generation of induced pluripotent stem cells
AssigneeThe Scripps Research Institute
InventorsYan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
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Abstract
The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
Claims18
1-20. (canceled)
A therapeutic composition comprising (i) an induced pluripotent stem cell reprogrammed from a mammalian non-pluripotent cell, and (ii) a small molecule composition comprising a GSK-3 inhibitor.
A composition comprising differentiated cells of a desired cell type derived from induced pluripotent stem (iPS) cells, wherein the iPS cells are comprised in a composition comprising a small molecule composition comprising a GSK-3 inhibitor.
A kit comprising (i) an induced pluripotent stem cell reprogrammed from a mammalian non-pluripotent cell, and (ii) a small molecule composition comprising a GSK-3 inhibitor.
A kit comprising differentiated cells of a desired cell type derived from induced pluripotent stem (iPS) cells, wherein the iPS cells are comprised in a composition comprising a small molecule composition comprising a GSK-3 inhibitor.
Dependencies are inferred from the claim text.