Methods of increasing delivery of anti-cancer agents to targets
AssigneeOncoquest Inc.
InventorsRagupathy Madiyalakan, Christopher F. Nicodemus, Michael A Hollingsworth
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Abstract
The present invention provides compositions and methods for increasing the permeability of a stroma around a neoplasm, and particularly to cancer cells associated with solid tumors. In one embodiment, combining a therapeutic IgE antibody with an anti-cancer agent in accordance with the invention increases the delivery of the anticancer agent to the site of, for example, a solid tumor in a subject. In one embodiment, combining a therapeutic IgE antibody with an anti-cancer agent in accordance with the invention potentiates a tumor's responsiveness and sensitivity to the anti-cancer agent.
Claims24
A method for increasing the permeability of a stroma around a neoplasm in a subject comprising administering to the subject, an effective amount of at least one IgE antibody specific for a cancer antigen, an antigen present in or around the stroma of a neoplasm, or a combination thereof.
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Dependencies are inferred from the claim text.