Cytotoxic benzodiazepine derivatives
AssigneeImmunoGen, Inc.
InventorsWei Li, Michael Louis Miller, Nathan Elliott Fishkin, Ravi V.J. Chari
Life of this patent
Estimating the term…
Abstract
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
Claims18
A conjugate represented by the following structural formula:
- or
- or a pharmaceutically acceptable salt thereof, wherein the antibody is huMy9-6, r is an integer from 1 to 10, Y is —SO3M, and M is —H or a pharmaceutically acceptable cation.
A method of treating leukemia in a human comprising administering to said human a therapeutically effective amount of a conjugate represented by the following structural formula:
- or
- or a pharmaceutically acceptable salt thereof, wherein the antibody is huMy9-6, r is an integer from 1 to 10, Y is —SO3M, and M is —H or a pharmaceutically acceptable cation.
Dependencies are inferred from the claim text.