Chimeric antigen receptors, compositions, and methods
AssigneeRegents of the University of Minnesota
InventorsDan Samuel KAUFMAN, David Lee LAMPI HERMANSON, Branden Scott MORIARITY
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Abstract
This disclosure describes chimeric antigen receptors for expression in a Natural Killer (NK) cell, pharmaceutical compositions that include NK cells (and/or iPSCs) modified to express a chimeric antigen receptor, and methods involving such chimeric antigen receptors. Generally, the chimeric antigen receptor includes an ectodomain that includes an antigen recognition region, a transmembrane domain linked to the ectodomain, and an endodomain linked to the transmembrane domain. The endodomain can include a signaling peptide that activates an NK cell.
Claims11
A chimeric antigen receptor comprising:
- an ectodomain comprising an antigen recognition region;
- a transmembrane domain linked to the ectodomain;
- and
- an endodomain linked to the transmembrane domain, the endodomain comprising a signaling peptide that activates an NK cell.
Dependencies are inferred from the claim text.