Humanized anti-trop-2 monoclonal antibodies and uses thereof
AssigneeAbruzzo Theranostic S.R.L.
InventorsEmanuela GUERRA, Saverio ALBERTI
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Abstract
The present invention refers to humanized anti-Trop-2 antibodies and their fragments, derivatives and conjugates that are able to recognise and bind with high affinity distinct regions of the Trop-2 molecule. The present invention also teaches the use of such antibodies and of pharmaceutical compositions thereof for diagnosis and therapy of human pathologies, in particular cancer.
Claims29
A humanized antibody, or fragments, derivatives or conjugates thereof, which recognizes and binds the same epitopes or epitope as the antibody 2EF produced by the hybridoma deposited in the Advanced Biotechnology Center (ABC) with the number PD 08021 or as the antibody 2G10 produced by the hybridoma deposited in the Advanced Biotechnology Center (ABC) with the number PD 08020.
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Dependencies are inferred from the claim text.