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US 2018/0002434 A1Published application
Methods of Using Interleukin-10 for Treating Diseases and Disorders
AssigneeArmo Biosciences, Inc.
InventorsJohn Brian Mumm, Ivan Ho Chan
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Abstract
Methods of treating subjects having a proliferative disease, disorder, or condition, including cancer, via the administration of an IL-10 agent, including pegylated IL-10, in combination with an antibody capable of inducing anti-body-dependent cell-mediated cytotoxicity, are provided.
Claims47
A method of treating or preventing a proliferative disease, disorder or condition in a subject, comprising administering to the subject:
- a) an antibody capable of inducing antibody-dependent cell-mediated cytotoxicity (ADCC), and
- b) an IL-10 agent in an amount sufficient to induce IL-18 in the serum.
A method of treating or preventing a proliferative disease, disorder or condition in a subject, comprising administering to the subject:
- a) an antibody capable of inducing ADCC, and
- b) an IL-10 agent in an amount sufficient to induce IL-18 in the serum and to maintain a mean IL-10 serum trough concentration over a period of time;
- and
- wherein the mean IL-10 serum trough concentration is at least 1.0 ng/mL, and
- wherein the mean IL-10 serum trough concentration is maintained for at least 90% of the period of time.
2 more elements
Dependencies are inferred from the claim text.