FAS AND DRs ARE NOVEL MOLECULAR TARGETS OF SENESCENT CELLS
AssigneeBioVentures, LLC
InventorsDaohong Zhou, Lijian Shao, Wei Feng, Yingying Wang, Jianhui Chang
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Abstract
The present invention relates to modulators of FAS and DRs and their method of use in the treatment and prevention of diseases and pathologies related to accumulation of senescent cells during aging, such as cancer, chronic obstructive pulmonary disease (COPD), osteoarthritis, atherosclerosis, neurodegenerative diseases, diabetes, and many others. The present invention also relates to pharmaceutical compositions containing these compounds as well as various uses thereof.
Claims30
A method of selectively killing one or more senescent cells in a subject in need thereof, the method comprising administering to the subject a composition comprising a compound that interacts with FAS and/or DRs and induces apoptosis.
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A method for delaying at least one feature of aging in a subject, the method comprising administering a composition comprising a therapeutically effective amount of a compound that interacts with FAS and/or DRs and induces apoptosis.
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A method of treating an age-related disease or condition, the method comprising administering a composition comprising a therapeutically effective amount of compound that interacts with FAS and/or DRs and induces apoptosis, provided the age-related disease or condition is not cancer.
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Dependencies are inferred from the claim text.