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US 2018/0002420 A1Published application
Monoclonal antibodies targeting killer immunoglobulin-like receptor (kir) family signaling
AssigneeTrellis Bioscience, LLC
InventorsAngeles ESTELLES, Mikhail GISHIZKY, Stefan RYSER, Lawrence M. KAUVAR
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Abstract
Monoclonal antibodies derived from the native human repertoire that bind the extracellular portion of Killer IgG Receptor (KIR) and pharmaceutical and veterinary compositions thereof are useful in treating cancer in human and other subjects.
Claims20
A monoclonal antibody (mAb) that binds an extracellular portion of an inhibitory Killer IgG-like Receptor (KIR), which mAb comprises:
- (a) the CDRs of the heavy chain variable region of TRL 8504 (SEQ ID NO:
- 1);
- (b) the CDRs of the heavy chain variable region of TRL 8507 (SEQ ID NO:
- 3);
- (c) the CDRs of the heavy chain variable region of TRL 8605 (SEQ ID NO:
- 5);
- or
- (d) the CDRs of the heavy chain variable region of TRL 8608 (SEQ ID NO:
- 7).
6 more elements
Dependencies are inferred from the claim text.