Antibody and antigen-binding fragment compositions targeting cell surface antigens in tumors and methods of use thereof
AssigneeUniversity of Connecticut
InventorsKEVIN P. CLAFFEY, CHARAN DEVARAKONDA, DANIEL KITA
Life of this patent
Estimating the term…
Abstract
Described herein is an isolated antibody or antigen-binding fragment including a heavy chain variable region including three heavy chain complementary determining regions (HCDRs), wherein the sequence of HCDR1 is GYRLSELS (SEQ ID NO: 1), the sequence of HCDR2 is ISGWDGNT (SEQ ID NO: 2), and the sequence of HCDR3 is ARASGYNY(SEQ ID NO: 3), wherein the isolated antibody or antigen-binding fragment specifically binds human HSP90, specifically HSP90 beta. Also included are detection and therapeutic methods using the isolated antibodies or antigen-binding fragments.
Claims21
An isolated antibody or antigen-binding fragment comprising a heavy chain variable region comprising three heavy chain complementary determining regions (HCDRs), wherein the sequence of HCDR1 is GYRLSELS (SEQ ID NO:
- 1), the sequence of HCDR2 is ISGWDGNT (SEQ ID NO:
- 2), and the sequence of HCDR3 is ARASGYNY(SEQ ID NO:
- 3), wherein the isolated antibody or antigen-binding fragment specifically binds human HSP90.
Dependencies are inferred from the claim text.