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US 2018/0002410 A1Published application
Methods of diagnosing and treating autism spectrum disorders
AssigneeThe Regents of the University of California
InventorsELLIOT H Sherr, Alireza Faridar
Life of this patent
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Abstract
The invention describes a method of diagnosing an individual as having an increased likelihood of having an autism spectrum disorder and in some instances, selecting a therapy. The invention is related to a system or a kit for performing such a method.
Claims15
A method of detecting whether an individual has an increased likelihood of having an autism spectrum disorder, the method comprising
- obtaining a sample from a human individual;
- detecting a quantity of phosphorylated and total amounts of ERK, PTEN and AKT protein in the sample;
- determining the ratio of (i) phosphorylated ERK to total ERK and (ii) phosphorylated PTEN to total PTEN and calculating the difference of the ratios from corresponding normal healthy control ratios, thereby generating a measure of difference of phosphorylated ERK and PTEN compared to control;
- comparing said measure to a ratio of phosphorylated AKT to total AKT of the individual, thereby generating a biomarker value;
- and
- analyzing the biomarker value relative a control value, thereby detecting the predicted likelihood of presence or absence of an autism spectrum disorder in the individual.
3 more elements
A system comprising
- a reagent that specifically detects phosphorylated ERK;
- a reagent that specifically detects total ERK;
- a reagent that specifically detects phosphorylated PTEN;
- a reagent that specifically detects total PTEN;
- a reagent that specifically detects phosphorylated AKT;
- a reagent that specifically detects total AKT;
- and
- a computer readable medium comprising instructions for:
- determining the ratio of (i) phosphorylated ERK to total ERK and (ii) phosphorylated PTEN to total PTEN and calculating the differences of those ratios from corresponding normal healthy ratios thereby generating a measure of difference of phosphorylated ERK and PTEN compared to controls;
- comparing said measure to a ratio of phosphorylated AKT to total AKT of the individual, thereby generating a biomarker value;
- and
- comparing the biomarker value to a control value.
9 more elements
A kit for detecting autism, the kit comprising
- a reagent that specifically detects phosphorylated ERK;
- a reagent that specifically detects total ERK;
- a reagent that specifically detects phosphorylated PTEN;
- a reagent that specifically detects total PTEN;
- a reagent that specifically detects phosphorylated AKT;
- and a reagent that specifically detects total AKT.
3 more elements
Dependencies are inferred from the claim text.