Human Anti-Tau Antibodies

A human monoclonal anti-tau antibody, or a tau binding fragment thereof which

• (i) is capable of binding recombinant human tau;
• (ii) is capable of binding pathologically modified tau;
• (iii) binds to pathologically aggregated tau at the pre-tangle stage, in neurofibrillary tangles (NFT), neuropil threads and/or dystrophic neurites in the brain
• (iv) does not substantially bind to physiological forms of tau in the brain;
• (v) specifically binds any one of tau isoforms B to F or fetal tau represented by SEQ ID NOs:
• 1 to 6;
• (vi) specifically binds a tau C-terminus;
• (vii) specifically binds a tau N-terminus
• (viii) specifically binds a tau epitope located in the microtubule binding domain which is masked in physiological microtubule-associated tau;
• (ix) specifically binds pathologically aggregated tau at the pre-tangle stage, in neurofibrillary tangles (NFT), neuropil threads and/or dystrophic neurites in the brain;
• (x) specifically binds a tau epitope which comprises the amino acid sequence of SEQ ID NO:
• 7;
• (xi) specifically binds a tau epitope which comprises the amino acid sequence of SEQ ID NO:
• 41;
• (xii) specifically binds a tau epitope which comprises the amino acid sequences of SEQ ID NO:
• 7 and 41;
• or
• (xiii) specifically binds a tau epitope which comprises the amino acid sequence of SEQ ID NO:
• 42.