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AssigneeMerus N.V.
InventorsHendricus Renerus Jacobus Mattheus Hoogenboom, Ton Logtenberg
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The present invention provides combinations of specific binding proteins, such as immunoglobulins, that are designed to be true combinations, essentially all components of the combination being functional and compatible with each other. The invention further provides a method for producing a composition comprising at least two different proteinaceous molecules comprising paired variable regions, the at least two proteinaceous molecules having different binding specificities, comprising paired variable regions, at least two proteinaceous molecules having different binding specificities, comprising contacting at least three different variable regions under conditions allowing for pairing of variable regions and harvesting essentially all proteinaceous molecules having binding specificities resulting from the pairing.
-43. (canceled)
An expression system for producing a heterogeneous combination of monospecific and bispecific antibodies, or antibody fragments of either thereof, wherein the heterogeneous combination has specific affinity for two target epitopes, the expression system comprising:
Dependencies are inferred from the claim text.