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US 2018/0002389 A1Published application
Compositions and Methods for Inhibiting Tumor Cells by Inhibiting the Transcription Factor ATF5
AssigneesThe Trustees of Columbia University in the City of New York, The Regents of the University of California
InventorsLloyd A. Greene, James Angelastro
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Abstract
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating dominant-negative ATF5 (“CP-d/n-ATF5”), wherein the CP-d/n-ATF5 is capable of inhibiting ATF5 function and/or activity.
Claims31
1-8. (canceled)
A cell-penetrating dominant-negative ATF5 molecule consisting essentially of:
- (i) a cell-penetrating peptide sequence selected from the group consisting of RQIKIWFQNRRMKWKK (SEQ ID NO:
- 34), YGRKKRRQRRR (SEQ ID NO:
- 40), and GRKKRRQRRRPPQ (SEQ ID NO:
- 41);
- (ii) a dominant-negative ATF5 sequence selected from the group consisting of LEQENAE (SEQ ID NO:
- 1), LEKEAEELEQENAE (SEQ ID NO:
- 2), LARENEELLEKEAEELEQENAE (SEQ ID NO:
- 3), and LEQRAEELARENEELLEKEAEELEQENAE (SEQ ID NO:
- 4);
- (iii) an ATF5 leucine zipper sequence selected from the group consisting of LEGECQGLEARNRELKERAESV (SEQ ID NO:
- 26), LEGECQGLEARNRELRERAESV (SEQ ID NO:
- 32), LEGECQGLEARNRELKERAES (SEQ ID NO:
- 53), and LEGECQGLEARNRELRERAES (SEQ ID NO:
- 54);
- and optionally (iv) one or more tags for isolation, purification, and/or identification.
12 more elements
Dependencies are inferred from the claim text.