FUSION PROTEINS OF NATURAL HUMAN PROTEIN FRAGMENTS TO CREATE ORDERLY MULTIMERIZED IMMUNOGLOBULIN Fc COMPOSITIONS
AssigneeGliknik Inc.
InventorsDavid S. BLOCK, Henrik OLSEN
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Abstract
The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. In comparison to the homodimeric fraction, purified multimeric stradomers have higher affinity and avidity for FcγRs with slower dissociation and are useful in the treatment and prevention of disease. The current invention demonstrates that directly linking IgG1 Fc regions to multimerization domains leads to enhanced multimerization and biological activity.
Claims16
1-156. (canceled)
A multimerized compound comprising two or more homodimeric stradomer units, wherein each homodimeric stradomer unit comprises an IgG1 Fc domain monomer directly linked at its carboxy terminus to an IgG2 hinge domain monomer wherein said IgG2 domain multimerizes the homodimeric stradomer units such that the multimerized compound is capable of binding to two or more Fc gamma receptors (FcγRs).
A multimerized compound comprising two or more homodimeric stradomer units, wherein each homodimeric stradomer unit consists of an IgG1 Fc domain monomer directly linked at its carboxy terminus to an IgG2 hinge domain monomer wherein said IgG2 domain multimerizes the homodimeric stradomer units such that the multimerized compound is capable of binding to two or more Fc gamma receptors (FcγRs).
Dependencies are inferred from the claim text.