Variants of group 5 allergens of the true grasses having reduced allergeneity due to mutagenesis of proline residues
AssigneeMerck Patent GmbH
InventorsMartin WALD, Andreas NANDY, Helmut FIEBIG, Bernhard WEBER, Helga KAHLERT, Gerald REESE, Oliver CROMWELL
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Abstract
The present invention relates to the preparation and use of recombinant variants of group 5 allergens of the Poaceae (true grasses), which are characterised by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.
Claims20
A hypoallergenic variant of a group 5 allergen of the true grass family (Poaceae) wherein the prolines which correspond in an alignment to the prolines in positions 57, 58, 117, 146, 155, 180, 211 in the amino acid sequence of wild-type Phl p 5.0109 have been mutated singly or in combinations.
Dependencies are inferred from the claim text.