Glut-1 as a receptor for htlv envelopes and its uses
AssigneesCentre National De La Recherche Scientifique, Universite Montpellier II
InventorsJean-Luc BATTINI, Nicolas MANEL, Felix KIM, Sandrina KINET, Naomi TAYLOR, Marc SITBON
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Abstract
The present application relates to a method for diagnosing a glucose transporter type 1 (GLUT1) deficiency syndrome that utilizes polypeptides derived from the soluble part of the glycoprotein of the enveloped virus of primate T-cell leukemia virus (PTLV). The polypeptides, named receptor binding domain ligands (RBD), are selected for their ability to bind specifically to GLUT1. The method involves determining the level of GLUT 1 expression at the cell surface and comparing the level to a reference value.
Claims19
A method for diagnosing a glucose transporter type 1 (GLUT1) deficiency syndrome, comprising:
- a) collecting sample from a subject,
- b) determining the level of GLUT1 expression at a cell surface using an isolated polypeptide, wherein said polypeptide is a soluble receptor binding domain (RBD) ligand derived from the soluble part of the glycoprotein of a primate T-lymphotropic virus binding to GLUT1 or a fragment thereof, and
- c) comparing said level to a reference value.
Dependencies are inferred from the claim text.