US 2018/0002380 A1Published application

Peptide for targeting autophagic cells and use thereof

AssigneeKyungpook National University Industry-Academic Cooperation Foundation

InventorsByung-Heon Lee, Bodhraj Acharya

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Abstract

The present invention relates to an autophagic cell targeted peptide and its use. More particularly, the present invention relates to a polypeptide comprising an amino acid sequence represented by the general formula (I) and specifically binding to an autophagic cell and a composition for detecting autophagic cells comprising the same as an active ingredient, a drug delivery composition containing the same as an active ingredient, and a composition for imaging comprising the same as an active ingredient. The peptide of the present invention specifically binds to the cell membrane of autophagic cells and can be applied to various kinds of tissues and cells. Also the detection and imaging effect of autophagy is remarkable in vitro and in vivo.

Claims20

Dependent claims

A polypeptide that specifically binds to an autophagic cell, comprising an amino acid sequence represented by the following general formula (I);

(amino-terminus-C-X1-X2-X3-X4-X5-X6-X7-C-carboxy-terminus) (I)
wherein C is cysteine,
X1 is any one of amino acid selected from the group consisting of lysine, glutamine, asparagine and proline;
X2 is any one of amino acid selected from the group consisting of histidine, glutamine, threonine and proline;
X3 is any one of amino acid selected from the group consisting of histidine, threonine, glycine and asparagine;
X4 is any one of amino acid selected from the group consisting of leucine, lysine, serine and threonine;
X5 is any one of amino acid selected from the group consisting of glycine, asparagine, proline and aspartic acid;
X6 is any one of amino acid selected from the group consisting of alanine, tyrosine and arginine;
X7 is any one of amino acid selected from the group consisting of isoleucine, tyrosine, glutamic acid and serine.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/687,219Filed 25 Aug 2017
Priority: KR 102015002856727 Feb 2015
Published: 4 Jan 2018
Term ends: Not estimatedThe source records don’t support an estimate.

Classification12 codes

C07K 7/06
Linear peptides containing only normal peptide links: having 5 to 11 amino acids
A61K 31/436
Ortho- or peri-condensed with heterocyclic ring systems: the heterocyclic ring system containing a six-membered ring having oxygen as a ring…
A61K 31/4706
Quinolines; Isoquinolines: 4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
A61K 47/50
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents…: the…