Back to results
US 2018/0002379 A1Published application
Methods and compositions for identification of highly specific nucleases
OwnerJeffrey C. Miller, Marcus B. Noyesinventors
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods and compositions for identification of specific DNA binding domains for constructing highly specific nucleases, which allows for pristine genome editing.
Claims27
A genetically modified cell or cell line wherein the modification comprises an insertion and/or deletion at or near any of SEQ ID NOs:
- 66, 94, 127, 128, or 129 within a hemoglobin beta (HBB) gene.
A zinc finger protein comprising the recognition helix regions in the order and sequence shown in Table A.
A genetically modified cell or cell line wherein the modification comprises an insertion and/or deletion at or near any of SEQ ID NOs:
- 28-33 or 142 within a CCR5 gene.
Dependencies are inferred from the claim text.