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US 2018/0002377 A1Published application
A process for purification of carfilzomib
AssigneeFresenius Kabi Oncology Limited
InventorsManeesh Kumar Pandey, Raj Narayan Tiwari, Sarbjot Singh Sokhi, Govind Singh, Saswata Lahiri, Walter Cabri
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Abstract
The present invention relates to a process for the purification of Carfiizomib of Formula I that reduces the level of an acetamide impurity of Formula II preferably below 0.10 wt %. Formula I Formula II.
Claims10
A process for purification of Carfilzomib of Formula I,
- comprising the steps of:
- (i) dissolving crude Carfilzomib in a first solvent and adding oxalic acid, to form Carfilzomib oxalate;
- (ii) precipitating said Carfilzomib oxalate;
- (iii) reacting said Carfilzomib oxalate with a base in a second solvent, to obtain the Carfilzomib.
1 more element
Oxalate salt of Carfilzomib having a structure of Formula (III),
Dependencies are inferred from the claim text.