Anti-microbial peptides and uses of same
AssigneeTechnion Research & Development Foundation Limited
InventorsNoam ADIR, Sharon NAVON, Tali SCHWARTZMAN
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Abstract
A method of treating a bacterial infection in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of a peptide being between 3 and 5 amino acids, wherein at least one amino acid of the 3 and 5 amino acids is selected from the group consisting of tryptophan, cysteine, proline and methionine.
Claims18
A method of treating a bacterial infection in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a peptide comprising the amino acid sequence selected from the group consisting of GPP, CKF, MCM, WKC, CKC, NMC, CQQ, WPR, MCP, MWT, QCW, DPP, FMC, HWM, WYT, HCW, PPW, WPC, YMW, CMR, CWS, GCW, IWC, IWW, PWW, WCS, NPC, WPP, WMW, CWY, HCC, WYC, FTW, IMH, KCM, HMC, QMC, CQW, PWC, CMM, IKC, IYM, PCM, VYM, CWP, HMY, PWM, CWK, MWY, TCH, WCQ, DWH, MHW, WFM, CWH, FKC, MWP, CBH, GWW, IQC, QCT, QCM, RQC, GCC, WMF, WPK, CQF, MCT, MCF, CEQ, CML, CWL, FEC, KCV, KQP, IWP and HNK, the peptide being no longer than 5 amino acids, wherein when said peptide comprises said amino acid sequence WPR said peptide is 3 amino acids long, thereby treating the bacterial infection.
An isolated anti-microbial peptide being between 3 and 5 amino acids, the peptide comprising the amino acid sequence selected from the group consisting of CKF, MCM, WKC, CKC, NMC, CQQ, WPR, MCP, MWT, QCW, DPP, FMC, HWM, WYT, HCW, PPW, WPC, YMW, CMR, CWS, GCW, IWC, IWW, PWW, WCS, NPC, WPP, WMW, CWY, HCC, WYC, FTW, IMH, KCM, HMC, QMC, CQW, PWC, CMM, IKC, IYM, PCM, VYM, CWP, HMY, PWM, CWK, MWY, TCH, WCQ, DWH, MHW, WFM, CWH, FKC, MWP, CBH, GWW, IQC, QCT, QCM, RQC, GCC, WMF, WPK, CQF, MCT, MCF, CEQ, CWL, FEC, KCV, KQP, IWP and HNK, wherein when said peptide comprises said amino acid sequence CQQ said peptide is 3 or 4 amino acids long and wherein when said peptide comprises said amino acid sequence WPR said peptide is 3 amino acids long.
A method of killing a microbe, the method comprising contacting the microbe with an isolated peptide comprising the amino acid sequence selected from the group consisting of GPP, CKF, MCM, WKC, CKC, NMC, CQQ, WPR, MCP, MWT, QCW, DPP, FMC, HWM, WYT, HCW, PPW, WPC, YMW, CMR, CWS, GCW, IWC, IWW, PWW, WCS, NPC, WPP, WMW, CWY, HCC, WYC, FTW, IMH, KCM, HMC, QMC, CQW, PWC, CMM, IKC, IYM, PCM, VYM, CWP, HMY, PWM, CWK, MWY, TCH, WCQ, DWH, MHW, WFM, CWH, FKC, MWP, CBH, GWW, IQC, QCT, QCM, RQC, GCC, WMF, WPK, CQF, MCT, MCF, CEQ, CML, CWL, FEC, KCV, KQP, IWP and HNK, the peptide being no longer than 5 amino acids, wherein when said peptide comprises said amino acid sequence WPR said peptide is 3 amino acids long, thereby killing the microbe.
Dependencies are inferred from the claim text.